PI3K/Akt信号通路在肿瘤发展和治疗中的作用

摘要

At present,multiple signaling networks were found in regulating the molecular mechanism of tumorigenesis, proliferation and apoptosis. PDK/Akt is one of the important signaling pathways, which is correlative with the genesis and progress of malignant tumors. Therefore, this paper sets forth the composition and regulating tumor mechanism of PDK/Akt signaling pathway, meanwhile, elucidates its clinical application and prospects.%目前发现有多条信号网络通路参与调控肿瘤生成、增殖、凋亡等分子机制,PI3K/Akt是其中比较重要的一条信号传导途径,该通路与肿瘤的发生发展密切相关.该文就PI3K/Akt信号通路的结构组成与调控肿瘤机制进行阐述,并介绍了其在临床中的应用与前景.