Objective To probe into the characteristics and regularity of adverse drug reactions in the city of Shangluo and to promote the level of reasonable medications as well as improve the quality of monitoring report. Methods 1 427 cases of ADR reports collected from 2009 to 2011 in our city were analyzed statistically in respects of the sex and age of patients,route of administration,causality of ADR, types of ADR-inducing drugs,major clinical manifestation,etc. Results In the 1 427 cases of ADR,medical institutions reported 984 cases , drug retail stores reported 443 cases, pharmaceutical production enterprise reported zero. ADRS caused by anti-infectives accounted for 47. 93% .traditional Chinese medicine and traditional Chinese medicine injection 22. 56% .intravenous drug 52. 42% ,oral medicines 39. 45% . Clinical manifestations were primarily damage to skin and accessories, 37. 63%. Conclusion In order to avoid ADR, we should strengthen and attach importance to monitoring the units involved with ADR,properly use anti-infective drugs as well as Chinese patent medicine and its injection.%目的 了解我市药品不良反应发生的特点和规律,促进合理用药水平,提高监测报告的质量.方法 对我市2009年至2011年上报的1 427例药品不良反应报告分别从患者的性别、年龄、给药途径、发生的原因、药品种类、临床表现等进行统计和分析.结果 1 427例药品不良反应报告中,医疗机构上报984例,药品零售店上报443例,药品生产企业报告数为零.抗感染药物引起的占47.93%,中成药及中药注射剂占22.56%;静脉给药引起占52.42%,口服药品占39.45%;临床表现以皮肤及附件损害最多占37.63%.结论 加强和重视药品不良反应在涉药单位的监测,注意抗感染药物与中成药及中药注射剂的合理使用;选择适宜的给药方法,避免不良反应的重复发生.
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