目的：探讨正常人唾液皮质醇、血浆皮质醇和24 h尿游离皮质醇三者之间的相关性。方法选择30例健康受试者同时检测唾液皮质醇、血浆皮质醇和24 h尿游离皮质醇。男子组和女子组各15例。采用化学发光技术测定，唾液标本采用唾液收集器收集，血标本为血浆，24 h尿液标本用硼酸防腐。结果唾液皮质醇和血浆、24 h尿液皮质醇在正常男女组之间均无显著性差异（P＞0．05），唾液皮质醇与血浆皮质醇（r＝0．91）、唾液皮质醇与24 h尿游离皮质醇（r＝0．95），均存在显著的相关性。结论唾液皮质醇可作为库欣氏综合征的筛查指标。%Objective To investigate the correlation among normal salivary cortisol ,plasma cortisol and 24-hour urine free cortisol of healthy human beings .Methods A total of 30 healthy subjects were selected and equally divided into male group and female group . The levels of salivary cortisol ,plasma cortisol and 24-hour urine free cortisol were detected by chemiluminescence technique .Salivary specimens were collected using salivary collector .Blood specimens were blood plasma .24-hour urine specimens were antisepticized by using boric acid .Results The levels of salivary cortisol ,plasma cortisol and 24-hour urine free cortisol showed no significant differ-ence between male group and female group (P>0.05).The correlation analysis results showed that the levels of three kinds of cortisol were highly related(P<0.001).Conclusions Salivary cortisol testing can be used as screening indicator of Cushing ’s syndrome.
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