滁菊总黄酮对寒凝血瘀证家兔血液流变学的影响

摘要

Objective To observe the effects of total flavonoids from Chuzhou Chrysanthemum morifolium Ramat on hemorheology in cold-coagulation and blood-stasis rabbits(CBR).Methods The model of CBR was induced by hypodermic injection of adrenalin com-bined with ice water soak.The effects of total flavonoids from Chuzhou Chrysanthemum morifolium Ramat on viscosity of whole blood and plasma,erythrocyte sedimentation rate and hematocrit,erythrocyte aggregation index and erythrocyte rigidity index,and platelet ag-gregation induced by ADP were determined in cold-coagulation and blood-stasis rabbits.Results Compared with model group,total fla-vonoids from Chuzhou Chrysanthemum morifolium Ramat could significantly reduce the viscosity of whole blood and plasma(P <0.05 or P <0.01),erythrocyte sedimentation rate and hematocrit(P <0.05 or P <0.01),decrease the erythrocyte aggregation index and eryth-rocyte rigidity index(P <0.05 or P <0.01),and inhibit platelet aggregation induced by ADP(P <0.05 or P <0.01).Conclusions The total flavonoids from Chuzhou Chrysanthemum morifolium Ramat could improve hemorheological abnormality of CBR.%目的：观察滁菊总黄酮对寒凝血瘀证家兔血液流变学的影响。方法采用皮下注射肾上腺素加冰水浸泡复制寒凝血瘀证家兔模型，观察滁菊总黄酮对寒凝血瘀证家兔全血黏度、血浆黏度，红细胞沉降速率和红细胞压积，红细胞聚集指数和刚性指数，以及二磷酸腺苷（ADP）诱导血小板聚集率的影响。结果与模型对照组比较，滁菊总黄酮能够改善寒凝血瘀证家兔全血黏度和血浆黏度（P ＜0．05或 P ＜0．01），降低红细胞沉降速率和红细胞压积（P ＜0．05或 P ＜0．01），降低红细胞聚集指数和刚性指数（P ＜0．05或 P ＜0．01），抑制 ADP 诱导的血小板聚集（P ＜0．05或 P ＜0．01）。结论滁菊总黄酮能够改善寒凝血瘀证家兔血液流变学异常。