枯草杆菌肠球菌二联活菌联合多烯磷脂酰胆碱治疗非酒精性脂肪性肝炎的疗效观察

摘要

Objective To investigate efficacy of capsule containing bacillus subtilis and enterococcus combined with phosphatidylcho -lines in treating non-alcoholic steatohepatitis(NASH)and its influence on serum levels of tumor necrosis factor(TNF)-αand interleu-kin(IL)-6.Methods One hundred eighteen cases with NASH were randomly assigned into control group(59 cases)and observation group(59 cases).All patients received non-drug treatment in accordance with the guidelines for the diagnosis and treatment of nonalco -holic fatty liver disease.Control group was given with polyene phosphatidylcholine(3 times/d and 2 grains/time).Based on therapy of control group,observation group was given with capsule containing bacillus subtilis and enterococcus(2 grains/time and tid).All pa-tients were treated for 3 months.Blood lipid,liver function,and efficacy were compared between two groups.Serum levels of TNF-αand IL-6 were detected in both groups.Results High density lipoprotein(HDL)of observation group was higher while low density lipopro-tein(LDL),total cholesterol(TC),triglycerides(TG),enzyme alanine aminotransferase(AST),alanine aminotransferase(ALT),and glutamyl transpeptidase(GGT)were lower than those in the control group after treatment(P<0.01).Total efficacy of observation group was 93.22%,which was higher than control group 79.66%(P<0.05).After treatment,serum levels of TNF-αand IL-6 were significantly lower than those in the control group(P<0.01).Conclusions Efficacy of Capsule containing bacillus subtilis and en-terococcus combined with phosphatidylcholines in treating NASH is definite and can inhibit serum levels of TNF -αand IL-6.%目的 探讨枯草杆菌肠球菌二联活菌联合多烯磷脂酰胆碱治疗非酒精性脂肪性肝炎(NASH)的疗效及对血清中肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平的影响.方法 118例NASH患者采用随机数字表法分为观察组(59例)和对照组(59例).两组患者依照《非酒精性脂肪性肝病诊疗指南》予非药物干预.对照组予多烯磷脂酰胆碱胶囊治疗,3次/天,2粒/次.观察组在对照组基础上口服枯草杆菌肠球菌二联活菌,3次/天,2粒/次.两组患者连续治疗3个月.比较两组血脂水平、肝功能和临床疗效.检测两组血清中TNF-α和IL-6水平.结果 治疗后,治疗组患者的高密度脂蛋白(HDL)明显高于对照组,低密度脂蛋白(LDL)、总胆固醇(TC)、三酰甘油(TG)、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)和谷氨酰转肽酶(GGT)明显少于对照组(P<0.01).观察组患者的总有效率为93.22%,对照组为79.66%,两组比较差异有统计学意义(P<0.05).治疗组患者治疗后血清中TNF-α和IL-6明显少于对照组,差异有统计学意义(P<0.01).结论 枯草杆菌肠球菌二联活菌联合多烯磷脂酰胆碱治疗NASH疗效明显,且可抑制血清中TNF-α和IL-6水平.