2型糖尿病合并下肢动脉病变相关危险因素研究

摘要

目的 探讨2型糖尿病合并下肢动脉病变的特点及相关危险因素.方法 对照组(CON)187例,2型糖尿病组(T2DM)288例,2型糖尿病合并下肢动脉病变组(T2DM+PAD)177例,比较各组间临床一般资料,糖、脂代谢相关指标并进行回归分析.结果 2型糖尿病合并下肢动脉病变组的年龄、收缩压与2型糖尿病组比较差异有统计学意义(P＜0.05).Logistic回归分析表明年龄、收缩压与2型糖尿病合并下肢动脉病变独立显著相关(年龄OR=1.076,95%CI=1.028～1.127,P=0.002;收缩压OR=1.028,95%CI=1.002～1.054,P=0.033).结论 高龄、收缩压可能是2型糖尿病合并下肢动脉病变的独立危险因素.%Objective To explore the characteristics and correlated risk factors of type 2 diabetes mellitus(T2DM) with peripheral arterial disease(PAD). Methods Based on case control study we compared the general clinical data and the correlated indexes about glucose or lipid metabolism among the group of 187 healthy people(CON) without type 2 diabetes mellitus, the group of 288 patients with type 2 diabetes mellitus( T2DM ) and the group of 177 patients with peripheral arterial disease in type 2 diabetes mellitus( T2DM + PAD). Results Age as well as systonic blood pressure (SBP) was significantly increased in T2DM + PAD group compared with T2DM (P ＜ 0.05 ). Logistic regression analysis showed that age or SBP was correlated independently and significantly with type 2 diabetes mellitus with peripheral arterial disease ( OR = 1. 076,95 ％ CI = 1. 028 ～ 1. 127, P = 0. 002 for age; OR = 1. 028, 95 ％ CI = 1. 002 ～ 1. 054, P = 0. 033 for SBP). Conclusion The results suggested that advanced age as well as SBP is an independent risk factor for type 2 diabetes mellitus with peripheral arterial disease.