Objective To study of estradiol benzoate intervention on bone metabolism in patients with premature ovarian failure. Methods 100 cases of patients with premature ovarian failure, as the observation group. At the same time, 100 healthy female patients, as control group. Study on bone mineral density and bone metabolic indexes, in two groups of patients. The patients in the observation group, divided into A, B two groups, 50 cases in each. Group A:50 patients were treated with estradiol benzoate. Group B:50 cases were treated with estrogen plus medroxyprogesterone acetate cycle sequential therapy. Results After treatment, Bone mineral density of the lumbar spine, femoral neck BMD, A group was lower than the control group, the difference was statistically significant (P< 0. 01). After treat-ment, Bone mineral density of the lumbar spine, femoral neck BMD, 25- hydroxyl Vitamin D3 level, B group was lower than the control group. Osteocalcin of B group was higher than in the control group, the difference was statistically significant (P< 0. 01). After treatment, patients with bone mineral density of the lumbar spine, femoral neck BMD, 25- hydroxyl Vitamin D3 level, A group were higher than those of B group, but osteocalcin, A group than in the B group, the difference was statistically significant (P<0. 01 or 0. 05). After treatment, two groups of estradiol level increased significantly, and the patients in group A was higher than that of B group, the difference was statistical-ly significant (P<0. 01). After treatment, patients in group A total cholesterol levels decreased significantly, and A group lower than in B group, the difference was statistically significant (P<0. 01). Conclusion Premature ovarian failure patients treated with estradiol benzo-ate, can effectively regulate bone metabolism of patients, reduce the incidence of osteoporosis, and no obvious adverse reaction, is worth the clinical promotion.%目的：探讨苯甲酸雌二醇对卵巢早衰患者骨代谢的影响。方法选择卵巢早衰患者100例作为观察组,同时选择100例健康女性患者作为对照组,观察两组患者的骨密度及骨代谢指标水平。将观察组患者分成A、B两组,各50例。 A组50例患者给予苯甲酸雌二醇治疗,B组50例患者给予结合雌激素联合醋酸甲羟孕酮周期序贯治疗。结果治疗后,A组腰椎骨密度、股骨颈骨密度低于对照组,两组比较差异具有统计学意义(P<0.01)；B组腰椎骨密度、股骨颈骨密度、25-羟维生素D3水平明显低于对照组,而骨钙素高于对照组,两组比较差异具有统计学意义(P<0.01)；A组患者腰椎骨密度、股骨颈骨密度、25-羟维生素D3水平均高于B组,而骨钙素低于B组,差异具有统计学意义(P<0.01或0.05)；两组雌二醇水平明显高于治疗前,且A组患者高于B组患者,差异具有统计学意义(P<0.01)；A组患者总胆固醇水平明显低于治疗前,且低于B组,差异具有统计学意义(P<0.01)。结论卵巢早衰患者给予苯甲酸雌二醇治疗,能有效地调理骨代谢情况,减少骨质疏松症的发生率,且无严重的不良反应,值得临床推广。
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