牙周治疗对孕期牙周指数及血清IL-1水平的影响

摘要

Objective To investigate the influence of periodontal treatment to the periodontal index and the serum Interleukin-1 (IL-1 )levels in pregnancy.Method Based on the periodontal health status,60 women in median pregnancy were enrolled and categorized as pe-riodontitis (PG,n=30),and control group (CG,n=30).The clinical periodontal measurements,including plaque index(PLI),probing depth (PD),clinical attachment loss (CAL),bleeding index(BI).Meanwhile,fasting peripheral blood sample was collected by venipuncture before periodontal treatment and after 4 to 6 weeks.The serum IL-1 level was quantified by ELISA.Result The serum IL-1 levels and each of the clinical parameters were significantly higher in PG group than those in CG group (P<0.05).After treatment,periodontal status improved sig-nificantly in PG group (P<0.05),between the CG the difference was not statistically significant (P>0.05).There is significant decrease in levels of IL-1at PG after periodontal treatment(P<0.05),between the CG the difference was not statistically significant (P>0.05).Conclu-sion Periodontal treatment during pregnancy can reduce the serum levels of IL-1 and improve the periodontal status.%目的：探讨牙周治疗对孕期牙周指数及血清白细胞介素-1（IL-1）水平的影响。方法选择60例中期妊娠妇女为研究对象，其中牙周炎30例，健康对照者30例。牙周炎组进行牙周治疗，分别与治疗前及治疗后4～6周检查菌斑指数（PLI）、探诊深度（PD）、临床附着丧失（CAL）和出血指数（BI）；同时抽取空腹静脉血5 mL，以ELISA法测定血清IL-1水平。结果牙周炎组和对照组之间，PLI、PD、CAL、BI和血清IL-1差异均有统计学意义（P＜0．05）；治疗后牙周炎组牙周状况明显改善（P＜0．05）且与正常对照组间差异无统计学意义（P＞0．05），血清IL-1水平较治疗前下降明显（P＜0．05），与正常对照组间差异无统计学意义（P＞0．05）。结论牙周治疗可降低孕期血清IL-1水平，改善牙周状况。