皮肤晚期糖基化终末产物与2型糖尿病周围神经病变的相关性研究

摘要

目的分析2型糖尿病（T2DM）伴周围神经病变（DPN）患者皮肤晚期糖基化终末产物（AGEs）水平变化及其临床意义。方法选择99例 T2DM 患者，依据神经缺陷评分（NDS）将其分为 DPN 组和非 DPN 组，同时选取正常对照组（NC 组）35例，测定各组皮肤 AGEs 和糖化血红蛋白（HbA1c）水平并进行比较。结果与 NC 组相比，T2DM 患者皮肤 AGEs 水平明显升高（P ＜0.05）；与非 DPN 组相比，DPN 组患者皮肤 AGEs 水平明显增（P ＜0.05），两组 HbA1c 水平差异无统计学意义（P ＞0.05）。结论T2DM 患者皮肤 AGEs 水平升高可能参与糖尿病周围神经病变的发生。%Objective To analyze the level changes and clinical significance of skin advanced glycation end products(SAGEs)in pa-tients of type 2 diabetes with peripheral neuropath. Methods According to Neurophy Disability Score,99 patients with type 2 diabetes were divided into two groups,DPN group and non-DPN group;and 35 cases of non-diabetic patients were selected as normal controls. Results Compared with normal control group,SAGEs level was obviously increased in patients with diabetes(P < 0. 05),compared with non-DPN group,the level of SAGEs also increased in DPN group. There was no significant difference in the HbA1c level between DPN group and non-DPN group(P > 0. 05). Conclusion The SAGEs level is obviously increased in patients with type 2 diabetes,which may be involved in the pathogenesis of DPN.