Objective To learn the risk factors and clinical features of acute leukemia patients with invasive fungal disease to pro-vide guidance for the diagnosis and treatment of invasive fungal disease. Methods The clinical data of 1 272 cases of acute leukemia pa-tients were studied retrospectively, and the risk factors associated with invasive fungal disease and its clinical features were statistically ana-lysed. Results The number of invasive fungal disease which occurred in 1 272 cases of acute leukemia patients was 124, the infection rate was 9. 75% and the site of infection was mainly in the lung and blood. The number of days in hospital, agranulocytosis duration and joint use time of broad-spectrum antibiotics were independent risk factors of invasive fungal infection. The main pathogen was Candida albicans, most of which was sensitive to amphotericin B and voriconazole. Conclusion Patients associated with acute leukemia are susceptible to invasive fungal disease. Candida albicans is the main pathogen, and during the treatment of primary disease, shortening the length of hospital stay, time to neutrophil recovery and strengthening support for treatment and rational use of broad-spectrum antibiotics can effectively reduce the in-cidence of invasive fungal disease.%目的：分析急性白血病( AL)患者侵袭性真菌病( IFD)的相关危险因素和临床特点，为IFD的诊断和治疗提供指导。方法对1272例AL患者进行回顾性研究，统计分析IFD的相关危险因素及临床特点。结果 1272例AL患者中发生IFD 124例，感染率为9．75%，感染部位以肺部和血液为主；住院天数、粒细胞缺乏持续时间和广谱抗菌药物联合使用时间是侵袭性真菌感染的独立危险因素；病原菌以白色念珠菌为主，多对两性霉素B和伏立康唑敏感。结论 AL患者是IFD的易感人群，以白色念珠菌感染为主，在治疗原发病的同时，缩短住院天数、粒细胞恢复时间，加强支持治疗及合理使用广谱抗菌药物，可有效降低IFD的发生。
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