心房颤动与恶性肿瘤相关性的研究进展

摘要

近年来,越来越多的流行病学研究指出相对于普通患者来说,恶性肿瘤患者发生心房颤动的风险更高,并且许多研究已经充分表明了恶性肿瘤与心房颤动的发生发展有着密切关系.虽然恶性肿瘤患者发生心房颤动的具体机制仍然不是十分明确,但基因、高龄、自主神经功能障碍、电解质紊乱、低氧、代谢紊乱可能是恶性肿瘤患者发生心房颤动的相关因素.因为出血风险的增加以及不可预测的抗凝反应,在癌症患者的心房颤动治疗上更具有挑战性,现就恶性肿瘤合并心房颤动相关性的研究进行综述.%During the decade, there are increasing epidemiologic studies indicated that patients with malignant tumor have a higher risk of atrial fibrillation (AF) and more and more studies have showed the close relationship between AF and malignant tumor. The mechanisms of the relevance are still not fullly understood, but gene, aging, autonomic nervous dysfunction, electrolyte disorder, hypoxia, metabolic disorders are likely toused to explain the question. Because of the higher bleeding risk and unpredictable anticoagulant response, it's more challenging in the treatment of this group patients. The correlation of malignant tumor with AF were reviewed in this paper.