胰高血糖素样肽1是体内一种重要的肠促胰素,能够通过多种途径降低血糖,在调节葡萄糖稳态中起重要作用,可用于预防和治疗糖尿病.胰高血糖素样肽1的受体分布广泛,除了胰腺组织外,还分布于脑、肺脏、心脏、肾脏等.近年来对胰高血糖素样肽1的研究发现其对心血管系统具有保护作用,如调节心率、血压,改善血管内皮功能、舒张血管、改善心肌缺血、改善心功能等.对这些作用的研究将为临床治疗糖尿病和心血管疾病提供新的方法.%Glucagon-like peptide-1 (GLP-I) is an incretin that lowers blood glucose through several mechanisms, and plays an impor-tant role in the regulation of glucose homeostasis. GLP-1 's function in glucose homeostasis may make it useful in the prevention and treatment of diabetes. GLP-1 may also be important in treating cardiac issues. The GLP-1 receptor is widely distributed in the body. It is found in the brain, lung, heart, kidney and the pancreas. Recent studies have shown that GLP-1 has a protective effect on the cardiovascular system. It has been found to regulate heart rate and blood pressure, relax vascular vessels, improve endothelial function, and protect ischemic myocar- , dium. Abnormalities of cardiovascular systems are common in diabetic patients. Further research into the effects of GLP-1 throughout the hu-man body may shed light on how it can be used in the treatment of diabetes and heart disease.
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