肾素-血管紧张素-醛固酮系统基因与高血压患者发生心血管事件相关性研究进展

摘要

心血管疾病是目前很多国家的主要死亡原因之一。另外高血压病是中国心血管疾病中发病率最高的疾病，血压的持续升高在心脑血管疾病的发生发展过程中起着重要作用。肾素-血管紧张素-醛固酮系统的过度激活是高血压机制之一。研究表明肾素-血管紧张素-醛固酮系统基因与心血管疾病、高血压、左室肥厚和心肌梗死有关。这些基因变异可能在整个生命活动中起作用，从而可能增加心脑血管疾病风险。但目前少见上述基因预测高血压患者发生心血管事件的研究，现就此问题进行综述。%Cardiovascular diseases are the leading cause of death in many countries.Hypertension has become the highest incidence of human disease in China, which plays an important role in the development of cardio-cerebrovascular disease.One of the mechanisms of hypertension is over-activation of renin-angiotensin-aldosterone system( RAAS).Study shows that some genes in RAAS are related to cardio-vascular disease, hypertension and myocardial infarction.Genetic mutations in RAAS may promote the occurrences of cardiovascular dis-ease.This article reviews the current research progress of how RAAS related genes correlate with cardiovascular disease in hypertensive pa-tients.