首发未治疗精神分裂症患者视觉引导眼跳中速度非对称与眼跳幅度相关性研究

摘要

Objective To explore the eye tracking dysfunction of schizophrenia , and to discuss the differences be-tween the correlation of speed asymmetry and amplitude of visually guided saccade for first period schizophrenic and the healthy.Methods Visually guided saccade was checked on 30 first-episode schizophrenia patients who met the criterion of ICD-10 as research group and 30 matched normal participated in control group .First, the acceleration asymmetry index (AAI) of each saccade was calculated; then, main sequence was taken in the two groups , and the general linear relation between acceleration peak , deceleration peak with amplitude of each participants was cal -culated ; third, the Raa values of first-episode schizophrenia and normal control group were compared .Results Compared with normal control group , Raa values of schizophrenia group were significantly lower (Mann-Whitney U test,Z =-3.567,P <0.01).Conclusion The finding suggests that Raa would be a potential biological marker to schizophrenia patients.%目的：探讨视觉引导眼跳中速度非对称性与眼跳幅度相关性在首发未治疗精神分裂症患者和健康者中的差异。方法选取符合 ICD－10诊断标准的首发、未治疗的精神分裂症患者30例，同时选取匹配的正常对照组30例，分别进行视觉引导眼跳检查。计算眼跳的加速度非对称指数（AAI），并计算 AAI 与眼跳幅度的相关系数 Raa。然后组间进行主序列分析，比较眼跳加速度峰值、减速度峰值等与眼跳幅度之间的一般线性关系，并进一步比较组间的 Raa。结果精神分裂症组 Raa 值低于正常对照组（Z ＝－3．567，P＜0．01）。结论Raa 可作为精神分裂症辅助诊断的一种生物学指标。