NLR、LMR和PLR与食管鳞癌患者预后的关系

摘要

目的 探讨中性粒细胞-淋巴细胞比值(NLR)、淋巴细胞-单核细胞比值(LMR)和血小板-淋巴细胞比值(PLR)预测食管鳞癌患者预后的价值.方法 回顾性分析接受治疗的1 061例食管鳞癌患者的临床资料,均经病理证实,计算初次诊断为食管鳞癌时NLR、LMR和PLR,分析 NLR、LMR和PLR与临床病理特征和预后的关系.结果 以 NLR =2. 46、LMR =200. 26 和 PLR =3. 88 为界,高 NLR 组患者的5年生存率为19. 10％,低NLR组的5年生存率为 47. 07％ (P< 0. 001),高LMR组患者的5年生存率为 57. 00％,低 LMR 组的 5 年生存率为 26. 00％ (P =0.006),高PLR组患者的5年生存率为40. 15％,低PLR组的5年生存率为42. 98％(P=0. 283).单因素分析显示性别、年龄、肿瘤标志物Cyfra21-1和鳞状细胞癌水平、食管癌分期、NLR水平、PLR水平、LMR水平均与患者预后显著相关(P< 0.05).用这些因素进行多因素Cox回归分析显示,性别、年龄、NLR水平、LMR水平是影响患者总体生存率的独立预后因素.结论 NLR和LMR是预测食管鳞癌患者预后的指标之一,NLR≥2. 46、LMR <200. 26 者生存期较短.%Objective To investigate the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio(LMR) and platelet-to-lymphocyte ratio (PLR) in patients with esophageal squamous cell carcinoma(ESCC). Methods A restropective review was performed on 1 061 patients who diagnosed ESCC. All patients were diagnosed with ESCC by pathological examination. Results Based on these cut-off value, NLR =2. 46, LMR =200. 26 and PLR =3. 88, the 5-year overall survival rate was 19. 10％ in patients of the high NLR group and 47. 07％ in those of the low NLR group(P＜ 0. 001). The 5-year overall survival rate was 57. 00％ in patients of the high LMR group and 26. 00％ in those of the low LMR group (P =0. 006). The 5-year overall survival rate was 40. 15％ in patients of the high PLR group and 42. 98％ in those of the low PLR group(P =0. 283). Single factor analysis showed that gender, age, esophageal stage, tumor markers Cyfra21-1 and squamous cell carcinoma antigen, NLR, PLR and LMR were significant correlated with the prognosis of patients (P＜ 0. 05). Multivariate Cox regression analysis showed that gender, age, NLR levels, and LMR levels were independent prognostic factors for overall survival in patients. Conclusion NLR and LMR are one of the predictors of prognosis in patients with esophageal squamous cell carcinoma, NLR ≥ 2. 46 and LMR ＜200. 26 have shorter survival time.