岗梅感冒灵颗粒流浸膏药效学研究

摘要

为对岗梅感冒灵颗粒流浸膏进行药效学研究,采用药理学模型对岗梅感冒灵颗粒流浸膏进行小鼠毒性、大鼠解热、小鼠抗炎、镇痛等药效学实验.结果显示岗梅感冒灵颗粒流浸膏毒性小,可抑制2,4-二硝基苯酚引起的大鼠体温升高,抑制二甲苯致小鼠耳肿胀和冰醋酸致小鼠腹腔毛细血管通透性增加,显著提高热刺激痛阈值,使扭体潜伏期延长,扭体次数减少.研究表明岗梅感冒灵颗粒流浸膏毒性低,具有解热、抗炎、镇痛作用,是一安全有效的中药复方制剂.%The study was aiming for the Pharmacodynamic of Gangmei Ganmaoling granule fluid extract.By using pharmacological model,the toxicity,and anti-inflammatory in mice,the antipyretic in rat,and analgesic effects of Gangmei Ganmaoling granule fluid extract were tested.The results showed that Gangmei Ganmaoling granule fluid extract has a low of toxicity.It can suppress the body temperature induced by 2,4-dinitrophenol in rats.The inflammatory swelling induced by xylene in ear of mice was alleviated.The capillary permeability induced by glacial acetic acid in mice was restrained.Analgesic study showed that the pain threshold of temperature stimuli was increased markedly in mice,the writhe incubation period was prolonged,and the number of writhe induced by abdominal of glacial acetic acid were decreased.In conclusion Gangmei Ganmaoling granule fluid extract was of low toxicity,with antipyretic,anti-inflammatory and analgesic effects,which proved to be a safe and effective compound preparation of traditional Chinese medicine.