结构DNA纳米技术应用新进展

摘要

DNA possesses extraordinary molecular recognition properties and remarkable structural features in the nano-level material regulation fields,which have shown enormous applications in many areas.In this review,we focus on DNA nanotechnology,including aspects ranging from modular DNA self-assembly to DNA origami,in addition to the recently reported novel assembly methods.Moreover,we summarize some applications of DNA nanotechnology,such as DNA-directed nanoparticle spatial positioning and orientation,and well-defined assembly of proteins on the DNA structure,as well as its uses,such as in the biomedical field,etc.The development and potential applications of DNA nanotechnology are also discussed.%DNA具有非凡的分子识别性能和显著的结构特征,这使得它在材料的纳米级调控方面具有独特的优越性,在许多领域也展现出广阔的应用前景.本文从模块化DNA自组装和DNA折纸术两个方面综述了近些年DNA纳米技术,包括近年来DNA纳米技术中比较新型的组装方法;并从DNA纳米结构作为模板定位纳米粒子和蛋白以及用于生物医药等方面介绍了DNA纳米技术的应用;同时,对DNA纳米技术发展及应用进行了展望.