长期服用一种自由基清除剂ONO-3144对易卒中自发高血压大鼠的影响

摘要

AIM: To clarify the preventive effects of ONO-3144, a free radical scavenger, on stroke-prone spontaneously hypertensive rats (SHRSP) and free radicals related to the hypertensive disorders. METHODS: Drugs with powdered chow were administered orally to the rats from 2- to 14-month-old. Body weight, blood pressure,rectal temperature, oxygen consumption rate, thyroid hormones, lipids, platelet number, ocular fundus,autopsy, and life span were investigated. RESULTS:ONO-3144 did not affect the growth, blood pressure,concentrations of thyroid hormones and lipids in the blood, but decreased the rectal temperature and oxygen consumption rate. ONO-3144 also prevented the platelet number decrease, sclerotic change of retinal artery,edematous and hypertrophic changes in parenchymal andcirculatory organs. Both the average life-span and the longest life time of SHRSP given 40 mg/kg ONO-3144were longer than those of normotensive rats and noadministration hypertensive rats. CONCLUSION: Theoxidative free radicals closely relate to hypertensioninduced pathophysiological changes in SHRSP, and ONO-3144 prevents the changes of those disorders, and then brings longevity.