State Key Laboratory of Bioreactor Engineering;
Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism;
Frontiers Science Center for Materiobiology and Dynamic Chemistry;
Shanghai Key Laboratory of New Drug Design;
School of Pharmacy;
East China University of Science and Technology;
Shanghai 200237;
China;
Shanghai East Hospital;
School of Life Sciences and Technology;
Tongji University;
Shanghai 200092;
China;
East China University of Science and Technology-Tengbai Pharmaceutical Innovative Drugs Joint Research Institute;
Zhuhai Tengbai Pharmaceutical Co.;
Ltd.;
Zhuhai 519000;
China;
Hubei Key Laboratory of Genetic Regulation and Integrative Biology;
School of Life Sciences;
Central China Normal University;
Wuhan 430079;
China;
Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from West Yunnan;
College of Pharmacy;
Dali University;
Dali 671000;
China;
Clinical Medicine Scientific and Technical Innovation Center;
Shanghai Tenth People's Hospital;
Tongji University School of Medicine;
Shanghai 200092;
China;
Key Laboratory of Tropical Biological Resources of Ministry of Education;
College of Pharmacy;
Hainan University;
Haikou 570228;
China;
Heart failure; SGLT2 inhibitor; Empagliflozin; Structural repurposing; NHE1(sodium-hydrogen exchanger 1);