甲状腺乳头状癌中砂粒体矿物学研究

摘要

砂粒体矿化对诊断甲状腺乳头状癌具有高度的特异性,对其矿物成分及形成机理的分析有望对研究肿瘤的发生发展过程提供辅助信息.本文以甲状腺乳头状癌中的同心层状砂粒体矿化作为研究对象,采用偏光显微镜、环境扫描电镜及其能谱、傅立叶变换红外光谱、电子探针和高分辨透射电子显微镜,对原位和分离处理样品的表面形貌、结构和矿物成分进行了观察测试.研究结果表明,甲状腺乳头状癌中砂粒体是由纳米尺寸的粒状、短柱状碳羟磷灰石及一些无定形低Ca/P(原子分数,下同)的磷酸钙矿物混合组成,砂粒体的同心层状构造具有微胶粒成因的特征,是结构和成分不同的直接反映,砂粒体中Ca、P及 Ca/P的分布具有从外向内逐渐升高的趋势.%The mineralization of the psammoma body has a high specificity in diagnosing papillary thyroid carcinoma, and an analysis of its mineral composition may provide some support information on the origin and development of the disease. Focusing on the concentric lamellated calcified bodies in papillary thyroid carcinoma, the authors used ESEM, EDAX, EPMA, FTIR and HRTEM to investigate the morphology, structure and mineral composition of the sample. The results show that the concentric lamellated structure has genetic characteristics of micromicellae, and that the psammoma bodies are composed of nano-size carbon hydroxyapatite and some amorphous calcium phosphates with relatively low values of Ca/P( At% ). The Ca, P and Ca/P(At% )in the psammoma body have an increasing tendency inwards.