核转录因子Nrf 2在帕金森病中的作用

摘要

Nuclear factor erythroid-2-realted factor 2(Nrf2) is an important transcription factor for cells to mediate the resistance to oxidative stress. As a pivotal protective mechanism, it binds to antioxidant response element(ARE) to resist internal and external oxidative stress. Recent studies have shown that the Keap1-Nrf2-ARE signaling pathway plays an important neuroprotective role in patients with Parkinson’s disease. In this paper,the role and its underlying mechanisms of Nrf2 in the treatment of Parkinson’s disease(PD),as well as the latest research achievements targeting Nrf2 for PD are summarized.%核因子E2相关因子2（nuclear factor erythroid-2-related factor 2，Nrf2）是细胞调节抗氧化应激反应的重要转录因子，其与抗氧化反应元件（anti-oxidative response element，ARE）结合，形成的Keap1-Nrf2-ARE信号通路是机体抵抗内、外氧化应激的关键保护性通路。现有研究显示Keap1-Nrf2-ARE信号通路对帕金森病患者具有重要的神经保护作用。该文对近年来Nrf2在治疗帕金森病方面的作用及其机制，以及以Nrf2为药物治疗靶点治疗帕金森病的最新研究成果进行总结。