目的: 探讨单片缬沙坦-氨氯地平复合制剂与氨氯地平缓释片自由联合用药治疗老年高血压的临床效果.方法: 选择2 级高血压的初治或血压控制不良的老年患者138 例,分为接受氨氯地平缓释片自由联合用药治疗(对照组70 例) 或单片缬沙坦-氨氯地平复合制剂治疗(观察组68 例).比较两组治疗前、治疗12 周后的血压情况和疗效,根据随访情况分析初始剂量的维持及长期血压控制情况.结果: 观察组治疗12 周后的收缩压和舒张压均低于对照组,两组比较差异有统计学意义(P＜0.05).治疗12 周后观察组总有效率为94.12％,高于对照组的81.43％,两组比较差异有统计学意义(P＜0.05).在1 年的观察过程中,观察组初始剂量的维持率和血压控制率分别为97.06％ 和 74.10％,优于对照组的87.14％和54.90％,两组比较差异有统计学意义(P＜0.05).结论: 在初始治疗及血压控制不良的患者中,缬沙坦-氨氯地平复合制剂在降压治疗的第1 年能改善血压情况,有较好的血压控制效果.%Objective: To study the clinical efficacy of Valsartan /Amlodipine compound preparation and Amlodipine sustained-release tablets based free combination therapy in the treatment of elderly hypertension. Methods: 138 cases of initially treated or poor controlled elderly patients with grade Ⅱ hypertension were enrolled, there were randomly assigned to receive Amlodipine sustained-release tablets based free combination therapy (control group, n =70) or Valsartan /Amlodipine compound preparation(observation group, n =68). The blood pressure and curative effect were compared between two groups before and after 12 weeks of treatment. The maintenance of initial dose and the control of long-term blood pressure were analyzed according to the follow-up. Results: The systolic and diastolic pressure of the observation group after 12 weeks was lower than those of the control group, and the difference was statistically significant (P＜0.05). After 12 weeks of treatment, the total effective rate of the observation group was 94.12％, higher than 81.43％ of the control group, and the difference was statistically significant (P＜0.05). During the 1-year follow-up, the initial dose maintenance rate and blood pressure control rate of the observation group were 97.06％ and 74.10％, better than 87.14％ and 54.90％ of the control group (P＜0.05). Conclusion: As for initially treated or poor controlled elderly patients, Valsartan / Amlodipine compound preparation can improve blood pressure in the first year of hypotensive treatment, presenting the clinical advantage of good blood pressure control.
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