Kinesin-2 家族在模式生物中的功能研究进展

摘要

Kinesin-2蛋白是Kinesin超级蛋白家族的一个亚家族,成员包括KIF3A, KIF3B, KIF3C以及KIF17.作为分子马达蛋白,Kinesin-2家族成员参与了细胞内多种蛋白复合体及囊泡的运输,对细胞行使各种生物学功能非常重要. 近年来发现Kinesin-2在纤毛内物质运输方面发挥重要作用,其功能缺陷可导致纤毛发育异常,进而影响组织器官的发育,并最终导致多种纤毛疾病的形成. 本综述将对近期Kinesin-2的研究进展进行介绍,将着重介绍kinesin-2家族成员在模式生物研究中的新进展.%Kinesin-2 family proteins, including KIF3A, KIF3B, KIF3C and KIF17, are members of the kinesin superfamily motor proteins , which transport various proteins and vesicles in the cell and play diverse biological functions . Recently, studies on members of kinesin-2 family proteins suggest that they play fundamental roles during ciliary transport , whose defects can lead to abnormal cilia development , the major cause of human ciliopathies .In this review , we will sum-marize the functions of this motor protein family during ciliogenesis and focus mainly on their roles in the development of model organisms .