金属螺旋三角形穴状化合物的组装及其对氨基葡萄糖的识别研究

摘要

利用含有丹磺酰胺荧光团和氢键作用位点的双三齿（N2O）有机配体H2L1[（N-（3,5-双（2-（2-吡啶亚甲基）甲酰肼基））苯基）-5-（二甲基氨基）萘-1-磺酰胺]与Zn2＋构筑金属螺旋三角形穴状化合物MC-1.通过荧光光谱、紫外光谱和ESI-MS测试及1H NMR测定,研究其对氨基葡萄糖和葡萄糖的识别与传感.结果表明,MC-1对氨基葡萄糖具有良好的荧光和紫外双重响应,而对葡萄糖却没有任何响应,且MC-1能够1∶1包合氨基葡萄糖,平衡常数lg Kass=7.23±0.03.%Metallohelical triangle cryptate MC-1 was assembled by Zn2＋ and two tridentate（N2O） ligand H2L1 [N-（3,5-bis（（E）-2-（pyridin-2-ylmethylene）hydrazinecarbonyl）phenyl）-5-（dimethylamino）napthalene-1-sulfonamide] with dansyl sulfonamide group and hydrogen bond site.UV-vis and fluorescence spectra,ESI-MS and 1H NMR of MC-1 were measured for recognition of glucosamine and glucose.It was found that MC-1 exhibited good response of UV-vis and fluorescene toward glucosamine,but no response for glucose.Moreover,1∶1 stoichiometric host-guest complexation of MC-1 for glucosamine was confirmed by the ti-tration profile and electrospray ionization mass spectrometry（ESI-MS） spectrum,with an association con-stant（lg Kass） being calculated as 7.23±0.03.