阿立哌唑对抗精神病药物所致高泌乳素血症的影响

摘要

Objective:To observe the effect of aripiprazole on hyperprolactinemia induced by antipsychotics.Methods:Ninety patients with hyperprolactinemia induced by antipsychotics were randomized into study group 1(aripiprazole 5 mg/day,n=30),study group 2(aripiprazole 10 mg/day,n=30),and control group(free from aripiprazole,n=30).Therapy duration was 8 weeks.Plasma prolactin levels were measured respectively at the baseline,4 and 8 weeks after medication.Positive and Negative Symptom Scale(PANSS) was used to evaluate the therapeutic effect,and Treatment Emergent Symptom Scale(TESS) to assess the adverse effect at the baseline and 8 weeks after therapy.Results:①Plasma prolactin level was significantly different in the two study groups before and after therapy(P<0.05);②There was no statistical difference between study group 1 and 2 regarding the plasma prolactin level following therapy(P>0.05),and the difference was not significant in the control group before and after therapy(P>0.05);③Scoring on the PANSS and TESS was not significant within and between study groups(P>0.05).Conclusion:Aripiprazole is effective to hyperprolactinemia induced by antipsychotics,and has dose-effect relation in therapy regimen.%目的:探讨阿立哌唑对抗精神病药物所引起的高泌乳素血症的影响.方法:将90例抗精神病药物所致高泌乳素血症患者随机分为3组,实验组一30例(阿立哌唑5 mg/d),实验组二30例(阿立哌唑10 mg/d),对照组30例未添加阿立哌唑治疗,治疗8周.分别于基线期、4周后、8周后监测血清泌乳素水平,于基线期及8周后采用PANSS量表评估疗效,TESS评估药物不良反应.结果:①实验组治疗前后泌乳素水平存在统计学差异(P<0.05);②实验组一和实验组二治疗后泌乳素水平无统计学差异(P>0.05),对照组治疗前后泌乳素水平无统计学差异(P>0.05);③实验组组间治疗后PANSS量表、TESS量表无统计学差异(P>0.05).结论:阿立哌唑能够改善抗精神病药物所引起的高泌乳素血症,且不存在量效关系.