ACYLPHENYLGLYCIN DERIVATIVE AND THIS PREVENTIVE AND HEALING AGENT CONTAINING ACTIVE SUBSTANCES AGAINST DISEASES CAUSED BY INCREASED COLLAGENASE ACTIVITY

摘要

An acylphenylglycine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, and a preventive and remedy for diseases caused by an increased collagenase activity containing the same as the active ingredient, wherein R1 represents hydrogen atom, methyl, methylaminomethyl or morpholinomethyl; R2 represents hydrogen atom, hydroxy, fluorine atom, or C1-C4 linear or branched alkyl; and R3 represents C1-C4 linear or branched alkyl. The compound (I) and the salt maintains a potent collagenase inhibitor activity in the blood for long after being administered, and are useful as a remedy for various diseases believed to be caused by an increased collagenase activity. CHEM IMAGE