新疆哈萨克族人神经前体细胞表达发育调控样蛋白4基因rs3865418多态性与中心性肥胖的相关性

摘要

Objective To investigate the relationships between rs3865418 polymorphism of neural precursor cell expressed developmentally downregulated 4-like gene and obesity in Kazakh general population. Methods Based on a cross-sectional epidemiological study in a Kazakh general population, a case-control study was conducted. The rs3865418 polymorphism in a Kazakh general population (856 subjects, including364 males and 492 females; 478 in obesity group and 378 in normal control group) was genotyped by TaqMan polymerase chain reaction, and the relationship between rs3865418 polymorphism and obesity was analyzed. Results The rs3865418 polymorphism was successfully genotyped in 851 Kazakh subjects. The distribution of the genotypes and alleles of rs3865418 polymorphism did not differ significantly between the obesity group and normal control group in terms of general populations, males, and females ( all P > 0. 05 ). The waist circumference showed a tendency of C/C > C/T > T/T in males and C/C < C/T < T/T in females, but without statistical significance (P>0. 05). Conclusions The rs3865418 polymorphism of neural precursor cell expressed de-velopmentally downregulated 4-like gene may not be associated with obesity in Kazakh general population. In other words, it is not a predisposing factor for obesity in Kazakh.%目的 研究哈萨克族人神经前体细胞表达发育调控样蛋白4(NEDD4L)基因rs3865418多态性与中心性肥胖的相关性.方法 以哈萨克族自然人群横断面流行病学调查为基础进行病例-对照研究.采用TaqMan PCR技术对rs3865418多态性在哈萨克族自然人群中(共856例,其中男性364例、女性492例；肥胖组478例、对照组378例)进行分型,分析其与哈萨克族人肥胖的相关性.结果 共有851例研究对象基因型分型成功,在总体、男性、女性哈萨克族自然人群中,rs3865418多态性的基因型、等位基因在肥胖组及对照组分布差异无统计学意义(P＞0.05)；男性腰围平均水平有C/C携带者＞C/T携带者＞T/T携带者的趋势,而女性腰围平均水平有C/C携带者＜C/T携带者＜T/T携带者的趋势,但差异无统计学意义(P＞0.05).结论 NEDD4L的rs3865418多态性与新疆哈萨克族中心性肥胖不相关,该变异可能不是哈萨克族人中心性肥胖的易感因素.