青少年库欣综合征患者的生长发育观察

摘要

Objective To elucidate the growth and development of patients with Cushing's syndrome (CS) in adolescence.Methods We analyzed the clinical data of 19 patients aged under 18 with CS.We divided the patients into two groups according to the height at diagnosis.The patients under the 3rd percentile were in the short stature group ( n = 12), and the others in the non-short stature group ( n = 7 ).The intergroup differences in disease course, age of onset, and 24-hour urinary free eortisol were analyzed.Results The median age at diagnosis was 13 years.The median disease course was 0.9 years.All those patients presented with typical clinical characteristics of CS.Twelve eases (63.2％) were in short stature group.The disease course of the short stature group was found significantly longer than that of the non-short stature group [(2.7 ± 1.7) years vs.(0.8 ± 0.6) years, P =0.013], but no significant difference was found in the age of onset (P =0.530) or 24-hour urinary free eortisol ( P =0.919 ) between the two groups.Conclusions The data suggest that short stature is common in adolescent CS patients.The growth delay may be correlated to the disease course of CS.%目的 分析并探讨青少年库欣综合征(CS)患者的生长发育特点.方法 回顾性分析19例青少年CS患者(年龄小于18岁)的临床特点.将患者按照来诊时身高在同年龄同性别正常青少年中的百分位数分为身材矮小组(第3百分位数以下,n=12)和非矮小组(第3百分位数以上,n=7),分析病程、发病年龄和24h尿游离皮质醇的组间差异.结果患者年龄中位数为13岁,病程中位数为0.9年.所有患者均有典型CS临床表现.12例患者(63.2%)来诊时身材矮小.身材矮小组患者的病程明显长于非矮小组[(2.7±1.7)年比(0.8±0.6)年,P=0.013],但两组间发病年龄(P＝0.530)和24h尿游离皮质醇水平(P＝0.919)差异无统计学意义.结论 青少年CS患者较普遍存在身材矮小的情况,身高延迟程度可能与CS病程长短有关.