Objective To study the blood coagulation before and after total hip arthroplasty (THA) and the effect of rivaroxaban on blood coagulation after THA. Methods Sixty-six patients who underwent THA in our department in 2011 were included in this study. They began to have oral rivaroxaban on day 1 after operation and received thromboelastography (TEG) before THA and on days 1 and 4 after THA. Difference in TEG findings at different stages was compared. Results TEG showed that the coagulation reaction time(r), blood cell clot formation time(k)and coagulation time(r+k)were significantly shorter while the blood cell clot formation rate(α), maximal amplitude (ma)and coagulation index(CI)were significantly higher after THA than before THA(P < 0.05). The r and r+k were significantly longer after taking rivaroxaban than before taking rivaroxaban(P<0.05). However, no significant difference was found in k,α, ma and CI before and after taking rivaroxaban. Conclusion THA can significantly increase blood coagulation and thrombosis risk. Short-term oral administration of rivaroxaban can decrease blood coagulation.% 目的研究血液凝固性在全髋关节置换术前、后的改变以及术后服用利伐沙班对其影响。方法随机选择2011年在我科行全髋关节置换术的患者66例。所有患者术后第1天开始口服利伐沙班，并分别于术前、术后第1天、术后第4天行血栓弹力图(thromboelastography，TEG)检查。比较各阶段TEG重要指标的差异。结果全髋关节置换术后TEG各指标中凝血反应时间(r)、血细胞凝集块形成时间(k)、凝血时间(r+k)值短于术前，血细胞凝集块形成速率(α)、最大振幅(ma)、凝血指数(CI)值高于术前，差异有统计学意义；术后服用利伐沙班后TEG各指标中r、r+k时间长于服药前，差异有统计学意义；k、α、ma、CI无显著变化，差异无统计学意义。结论全髋关节置换术可明显增加患者的血液凝固性，而增加血栓风险；术后短期口服利伐沙班可降低血液凝固性。
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