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Low-Power, Low-Voltage Electroosmotic Actuator for an Implantable Micropumping System Intended for Drug Delivery Applications.

机译:适用于药物输送应用的可植入式微泵系统的低功率,低电压电渗致动器。

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摘要

An electroosmotic (EO) actuator offers a low-power, low-voltage alternative in a diaphragm-based periodic displacement micropump intended for an implantable drug delivery system. The actuator utilizes an electroosmosis mechanism to transport liquid across a membrane to deflect the pumping diaphragms in a reciprocating manner. In the study, the membrane made of porous nanocrystalline silicon (pnc-Si) tens of nanometers in thickness was used as the promising EO generator with low power consumption and small package size. This ultrathin membrane provides the opportunity for electrode integration such that the very high electric field can be generated across the membrane with the applied potential under 1 volt for low flow rate applications like drug delivery. Due to such a low applied voltage, the challenge, however, imposes on the capability of generating the pumping pressure high enough to deflect the pumping diaphragms and overcome the back pressure normally encountered in the biological tissue and organ.;This research identified the cause of weak pumping pressure that the electric field inside the orifice-like nanopores of the ultrathin membrane is weaker than conventional theory would predict. It no longer scales uniformly with the thickness of membrane, but with the pore length-to-diameter aspect ratio for each nanopore. To enhance the pumping performance, the pnc-Si membrane was coated with an ultrathin Nafion film. As a result, the induced concentration difference across the Nafion film generates the osmotic pressure against the back pressure allowing the EO actuator to maintain the target pumping flow rate under 1 volt.
机译:电渗(EO)致动器在旨在用于植入式药物输送系统的基于隔膜的周期性位移微型泵中提供了低功率,低压替代方案。致动器利用电渗机制在膜上传输液体,以使泵送隔膜往复运动。在这项研究中,由数十纳米厚的多孔纳米晶体硅(pnc-Si)制成的膜被用作有前途的EO发生器,其功耗低且封装尺寸小。这种超薄膜为电极集成提供了机会,从而可以在膜片上产生极高的电场,施加的电势在1伏以下,适用于低流速应用(如药物输送)。由于如此低的施加电压,因此,挑战在于产生足够高的泵压以偏转泵隔膜并克服生物组织和器官中通常遇到的背压的能力。弱的泵送压力表明超薄膜的孔状纳米孔内部的电场比传统理论所预测的要弱。它不再随膜的厚度均匀缩放,而是随每个纳米孔的孔径与直径的长宽比变化。为了增强泵送性能,在pnc-Si膜上涂覆了超薄的Nafion膜。结果,Nafion薄膜上的感应浓度差产生了反压的渗透压,从而使EO致动器将目标泵送流量保持在1伏以下。

著录项

  • 作者

    Getpreecharsawas, Jirachai.;

  • 作者单位

    Rochester Institute of Technology.;

  • 授予单位 Rochester Institute of Technology.;
  • 学科 Biomedical engineering.;Nanotechnology.;Mechanical engineering.
  • 学位 Ph.D.
  • 年度 2015
  • 页码 191 p.
  • 总页数 191
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 公共建筑;
  • 关键词

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