ox-Behnken designs are used to estimate parameters in a second-order response surface model (Box and Behnken, 1960). These designs are formed by combining ideas from incomplete block designs (BIBD or PBIBD) and factorial experiments, specifically 2;In this dissertation, a more general mathematical formulation of the Box-Behnken method is provided, a general expression for the coefficient matrix in the least squares analysis for estimating the parameters in the second order model is derived, and the properties of Box-Behnken designs with respect to the estimability of all parameters in a second-order model are investigated when 2;In order to reduce the number of experimental points the use of 2;The final topic is concerned with Box-Behnken designs in which treatments are applied to experimental units sequentially in time or space and in which there may exist a linear trend effect. For this situation, one wants to find appropriate run orders for obtaining a linear trend-free Box-Behnken design to remove a linear trend effect so that a simple technique, analysis of variance, instead of a more complicated technique, analysis of covariance, to remove a linear trend effect can be used. Construction methods for linear trend-free Box-Behnken designs are introduced for different values of block size (for the underlying PBIB design) k. For k = 2 or 3, it may not always be possible to find linear trend-free Box-Behnken designs. However, for
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