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Interferometric characterization of tear film dynamics.

机译:泪膜动力学的干涉表征。

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摘要

The anterior refracting surface of the eye is the thin tear film that forms on the surface of the cornea. When a contact lens is on worn, the tear film covers the contact lens as it would a bare cornea, and is affected by the contact lens material properties. Tear film irregularity can cause both discomfort and vision quality degradation. Under normal conditions, the tear film is less than 10 microns thick and the thickness and topography change in the time between blinks. In order to both better understand the tear film, and to characterize how contact lenses affect tear film behavior, two interferometers were designed and built to separately measure tear film behavior in vitro and in vivo.;An in vitro method of characterizing dynamic fluid layers applied to contact lenses mounted on mechanical substrates has been developed using a phase-shifting Twyman-Green interferometer. This interferometer continuously measures light reflected from the surface of the fluid layer, allowing precision analysis of the dynamic fluid layer. Movies showing this fluid layer behavior can be generated. The fluid behavior on the contact lens surface is measured, allowing quantitative analysis beyond what typical contact angle or visual inspection methods provide. The in vivo interferometer is a similar system, with additional modules included to provide capability for human testing. This tear film measurement allows analysis beyond capabilities of typical fluorescein visual inspection or videokeratometry and provides better sensitivity and resolution than shearing interferometry methods.
机译:眼睛的前屈光表面是在角膜表面形成的薄泪膜。当隐形眼镜戴在身上时,泪膜会像裸露的角膜一样覆盖隐形眼镜,并受隐形眼镜材料特性的影响。泪膜不规则会导致不适感和视觉质量下降。在正常情况下,泪膜的厚度小于10微米,眨眼之间的时间间隔中,厚度和形貌会发生变化。为了更好地理解泪膜并表征隐形眼镜如何影响泪膜行为,设计并制造了两个干涉仪,以分别测量体内和体外的泪膜行为。使用相移的Twyman-Green干涉仪已经开发出一种用于在机械基板上安装隐形眼镜的装置。该干涉仪连续测量从流体层表面反射的光,从而可以对动态流体层进行精确分析。可以生成显示此流体层行为的影片。测量了隐形眼镜表面上的流体行为,可以进行超出典型接触角或目测方法所能提供的定量分析。体内干涉仪是一个类似的系统,包括附加模块以提供人体测试功能。这种泪膜测量允许进行超出典型的荧光素视觉检查或角膜曲率分析法的分析,并提供比剪切干涉法更好的灵敏度和分辨率。

著录项

  • 作者

    Primeau, Brian Christopher.;

  • 作者单位

    The University of Arizona.;

  • 授予单位 The University of Arizona.;
  • 学科 Optics.
  • 学位 Ph.D.
  • 年度 2011
  • 页码 301 p.
  • 总页数 301
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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