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High order Large Eddy Simulation of unpowered and powered Fontan hemodynamics in idealized and patient specific geometries.

机译:在理想化和特定于患者的几何形状中无动力和动力Fontan血流动力学的高阶大涡模拟。

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摘要

Children born with univentricular heart disease typically must undergo three open heart surgeries within the first 2-3 years of life to eventually establish the Fontan circulation. In that case the single working ventricle pumps oxygenated blood to the body and blood returns to the lungs flowing passively through the Total Cavopulmonary Connection (TCPC) rather than being actively pumped by a subpulmonary ventricle. A mechanical pump inserted into this circulation providing a 3-5 mmHg pressure augmentation would reestablish bi-ventricular physiology serving as a bridge-to-recovery, bridge-to-transplant or destination therapy as a "biventricular Fontan" circulation. A Viscous Impeller Pump (VIP) situated in the center of the 4-way TCPC intersection is studied here. We hypothesized that Large Eddy Simulation (LES) using high-order numerical methods is needed to capture unsteady powered and unpowered Fontan hemodynamics. Inclusion of a mechanical pump into the CFD further complicates matters due to the need to account for rotating machinery. Validation of the code is provided for an Idealized Medical Device, as well as for idealized TCPC simulations. Multiblock capabilities are added to the solver to allow for easier setup of complex geometries. Fontan hemodynamics is studied for both Unpowered and Powered cases on both Idealized and Patient specific geometries. Models to estimate blood damage and improve boundary conditions are also proposed.
机译:患有单心室心脏病的儿童通常必须在出生后的2-3年内进行三次心脏直视手术,以最终建立Fontan循环。在这种情况下,单个工作心室将充氧的血液泵送到人体,血液返回肺部,通过总腔肺连接(TCPC)被动地流动,而不是由肺下腔室主动泵送。插入该循环中以提供3-5 mmHg压力增加的机械泵将重新建立双心室生理功能,以作为“双心室Fontan”循环作为桥接至恢复,桥接至移植或目的地疗法。本文研究了位于四通TCPC交叉点中心的粘性叶轮泵(VIP)。我们假设需要使用高阶数值方法的大涡模拟(LES)来捕获不稳定的动力和无动力的Fontan血流动力学。由于需要考虑旋转机械,因此将机械泵包含在CFD中会使情况变得更加复杂。为理想化的医疗设备以及理想化的TCPC模拟提供了代码验证。多块功能已添加到求解器,以简化复杂几何的设置。在理想化和患者特定的几何形状下,对无动力和动力情况下的方丹血流动力学进行了研究。还提出了估计血液损害和改善边界条件的模型。

著录项

  • 作者

    Delorme, Yann.;

  • 作者单位

    Purdue University.;

  • 授予单位 Purdue University.;
  • 学科 Biomechanics.
  • 学位 Ph.D.
  • 年度 2013
  • 页码 238 p.
  • 总页数 238
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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