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Ultrawideband radar-based detection and classification of breast tumors.

机译:基于超宽带雷达的乳腺肿瘤检测和分类。

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摘要

Microwave imaging has the potential to be a highly sensitive modality for breast cancer detection. The rationale for using microwaves to detect breast tumors is the dielectric-properties contrast that exists between malignant and normal breast tissue at microwave frequencies. This malignant-to-normal dielectric contrast, reported to be 2:1 or higher, implies that even small malignant tumors exhibit relatively large radar cross sections that can be exploited for non-invasive detection, localization and characterization of tumors in the breast.; We investigate three ultrawideband (UWB) radar techniques for detecting and localizing tumors in numerical breast phantoms. The detectors operate on array backscatter data in the 1-11 GHz band and are based on a penalized least-squares beamformer design, a generalized likelihood ratio test (GLRT), and a penalized expectation-maximization (EM) algorithm. We demonstrate the capability of detecting small ( 1 cm) tumors through several examples and investigate robustness to mismatch between the actual and assumed scattering scenarios.; One of the foremost challenges faced by radar-based detection techniques is the clutter that arises due to scattering within normal heterogeneous breast tissue. We address this issue by first conducting a statistical characterization of clutter computed from 3-D MRI-derived breast phantoms. Then we mitigate the clutter by implementing a whitening transformation based on a parametric model for the clutter covariance matrix. Incorporating this whitening transformation into our detector designs, we show a significant reduction in falsely-detected clutter.; Finally, we consider the problem of classifying salient tumor characteristics from the radar data. The shape and size of a tumor are compelling classification features that may be indicative of the nature of a tumor. Using a basis expansion approach and a simple linear classifier design, we demonstrate shape and size classification on backscatter obtained from a variety of 3-D numerical tumor models. This feasibility study indicates that both the tumor size and shape have the potential to be reliably classified directly from backscatter data. In this manner, tumor classification may be seamlessly integrated with UWB radar detection without requiring any special hardware or additional data collection.
机译:微波成像有可能成为乳腺癌检测的高度灵敏手段。使用微波检测乳腺肿瘤的基本原理是在微波频率下恶性和正常乳腺组织之间存在介电特性对比。据报道,这种恶性与正常的介电对比为2:1或更高,这意味着即使是小的恶性肿瘤也具有相对较大的雷达横截面,可用于乳腺肿瘤的非侵入性检测,定位和表征。我们调查了三种超宽带(UWB)雷达技术,用于检测和定位数字化人体模型中的肿瘤。这些检测器对1-11 GHz频带中的阵列反向散射数据进行操作,并基于惩罚最小二乘波束形成器设计,广义似然比测试(GLRT)和惩罚最大期望(EM)算法。我们通过几个例子证明了检测小肿瘤(<1 cm)的能力,并研究了在实际和假定散射情况之间不匹配的鲁棒性。基于雷达的检测技术面临的首要挑战之一是由于正常异质乳房组织内的散射而引起的混乱。我们首先对从3D MRI衍生的乳房幻像计算出的杂波进行统计表征,以解决这个问题。然后,我们通过基于杂波协方差矩阵的参数模型实施白化变换来减轻杂波。将这种增白变换结合到我们的检测器设计中,我们可以大大减少错误检测到的杂波。最后,我们考虑根据雷达数据对突出肿瘤特征进行分类的问题。肿瘤的形状和大小是令人信服的分类特征,可以指示肿瘤的性质。使用基础扩展方法和简单的线性分类器设计,我们演示了从各种3D数值肿瘤模型获得的反向散射的形状和尺寸分类。这项可行性研究表明,肿瘤大小和形状都有可能直接从反向散射数据中可靠地分类。以这种方式,可以将肿瘤分类与UWB雷达检测无缝集成,而无需任何特殊硬件或额外的数据收集。

著录项

  • 作者

    Davis, Shakti K.;

  • 作者单位

    The University of Wisconsin - Madison.;

  • 授予单位 The University of Wisconsin - Madison.;
  • 学科 Engineering Biomedical.; Engineering Electronics and Electrical.
  • 学位 Ph.D.
  • 年度 2006
  • 页码 165 p.
  • 总页数 165
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;无线电电子学、电信技术;
  • 关键词

  • 入库时间 2022-08-17 11:40:44

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