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Numerical solutions of an immunology model using reaction -diffusion equations with stochastic source terms.

机译:使用带有随机源项的反应扩散方程的免疫学模型的数值解。

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摘要

When immune cells detect foreign molecules, they secrete soluble factors that attract other immune cells to the site of the infection. In this thesis, I study numerical solutions to a model of this behavior proposed by Thomas Kepler. The soluble factors are governed by a system of reaction-diffusion equations with sources that are centered on the cells. The motion of the cells is stochastic, but biased toward the gradient of the soluble factors. The solution to this system exists for all time and remains positive, the supremum is a priori bounded and the derivatives are bounded for finite time. I have developed a numerical method for solving the reaction-diffusion stochastic system based on a first order splitting scheme. This method makes use of known first order schemes for solving the diffusion, the reaction and the stochastic differential equations separately. The domain is discretized using finite elements and the diffusion is solved using a backward Euler scheme combined with multigrid. The stochastic differential equations are solved using a Milstein scheme, making use of the fact the noise is commutative.
机译:当免疫细胞检测到外来分子时,它们会分泌可溶因子,将其他免疫细胞吸引到感染部位。在本文中,我研究了由Thomas Kepler提出的这种行为模型的数值解。可溶性因子由反应扩散方程系统控制,其来源以细胞为中心。细胞的运动是随机的,但偏向可溶性因子的梯度。该系统的解一直存在,并且一直为正,至高点是先验有界的,导数有界是有限的。我已经开发出一种基于一阶拆分方案求解反应扩散随机系统的数值方法。该方法利用已知的一阶方案分别求解扩散,反应和随机微分方程。使用有限元对域进行离散化,并使用后向Euler方案结合多网格来解决扩散问题。利用噪声是可交换的事实,使用Milstein方案求解随机微分方程。

著录项

  • 作者

    Lucas, Timothy A.;

  • 作者单位

    Duke University.;

  • 授予单位 Duke University.;
  • 学科 Mathematics.
  • 学位 Ph.D.
  • 年度 2006
  • 页码 116 p.
  • 总页数 116
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-17 11:40:20

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