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Mathematical analysis of an integro-differential equation arising in neuroscience.

机译:神经科学中积分微分方程的数学分析。

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摘要

In this dissertation, I study the class of nonlinear integro-differential equations 6u&parl0;x,t&parr0;6t =-u&parl0;x,t&parr0;+-infinityinfinity wx-yf&parl0;u&parl0; y,t&parr0;-q&parr0;dy +h. These equations arise in neuroscience for modeling short-term memory and were introduced by Shun-ichi Amari in 1977. Here u( x, t) is the average membrane potential of the neurons, w(x) accounts for the coupling between neurons and is of Mexican-hat type, and f(u) is the firing rate of a neuron with input u, taken to be a Heaviside step function. Finally, the parameter h denotes a constant external stimulus applied uniformly.; I will study the patterns exhibited by these equations. A region of neuronal excitation is a set R(u) = {lcub}x| u(x) > 0{rcub}. If R(u) is a finite, connected, open interval, the pattern is a "1-bump" solution. If R(u) consists of N > 1 disjoint, finite, connected, open intervals, then the solution is called an N-bump solution.; For 1-bump solutions, I review the Amari existence theorem and establish necessary and sufficient conditions for their existence. Then, I study the stability of 1-bump solutions. In previous work, perturbations of the endpoints of the intervals of the excited region were considered. This criterion is a necessary condition for stability. However, one must also account for shape changes. Hence, the questions arise here whether this elementary condition is also sufficient and whether there is some rigidity in these solutions that their properties (lengths, heights) are related. To this end, I carry out a classical stability analysis, and I show that this criterion is also sufficient to establish their linear stability.; For 2-bump solutions, I show that the necessary criteria for the existence of equal width 2-bump solutions, developed by William Troy and Carlo Laing, are sufficient as well, with one extra, natural condition. Further, I explore 1-bump solutions with a dimple and show that for some coupling functions it is possible for this type of solution to become a 2-bump solution. In addition, I generalize the 2-bump results to N-bump solutions, as well as to spatially periodic solutions, identifying their origins in classical Turing bifurcations.; One of the main analytical techniques I use is to approximate w(x) by a piecewise linear function that shapes the essential qualitative and quantitative properties of smooth w (x). This facilitates determining how solution properties depend on the parameters and characteristics of w( x).; In addition, I study the steady-state equation as an example of a broad class of nonlinear integral equations known as Hammerstein equations. We will use the calculus of variations to study this equation with the energy function constructed by Donald French.
机译:在本文中,我研究了非线性积分-微分方程6u&parl0; x,t&parr0; 6t = -u&parl0; x,t&parr0; +-无穷无穷wx-yf&parl0; u&parl0; y,t&parr0; -q&parr0; dy + h。这些方程式是在神经科学中用于建模短期记忆的方程式,由Shun-ichi Amari于1977年引入。此处u(x,t)是神经元的平均膜电位,w(x)解释了神经元之间的耦合,且f(u)是具有输入u的神经元的放电速率,它是Heaviside阶跃函数。最后,参数h表示均匀施加的恒定外部刺激。我将研究这些方程式所显示的模式。神经元兴奋的区域是集合R(u)= {lcub} x |。 u(x)> 0 {rcub}。如果R(u)是有限的,连通的打开间隔,则该模式是“ 1-凸点”解决方案。如果R(u)由N> 1个不相交的,有限的,连通的,开放的区间组成,则该解称为N凸点解。对于1凸点解,我回顾了Amari存在定理,并为其建立了必要和充分的条件。然后,我研究了1凸点解决方案的稳定性。在以前的工作中,考虑了受激区域间隔的端点的摄动。此标准是稳定的必要条件。但是,还必须考虑形状的变化。因此,这里出现的问题是,该基本条件是否也足够,并且在这些解决方案中是否存在一些与它们的属性(长度,高度)相关的刚性。为此,我进行了经典的稳定性分析,并且表明该标准也足以建立其线性稳定性。对于2凸点解决方案,我证明了由William Troy和Carlo Laing开发的等宽2凸点解决方案存在的必要条件也足够了,并且有一个额外的自然条件。此外,我探索了带有凹痕的1-bump解决方案,并表明对于某些耦合函数,这种类型的解决方案有可能变为2-bump解决方案。另外,我将2个凸点的结果推广到N凸点解以及空间周期解中,确定它们在经典图灵分叉中的起源。我使用的主要分析技术之一是通过分段线性函数来近似w(x),该线性函数塑造了光滑w(x)的基本定性和定量性质。这有助于确定解的性质如何取决于w(x)的参数和特征。另外,我将稳态方程作为称为Hammerstein方程的一类广泛的非线性积分方程的示例进行研究。我们将使用变分的微积分来研究唐纳德·弗兰奇(Donald French)构建的能量函数方程。

著录项

  • 作者单位

    Boston University.;

  • 授予单位 Boston University.;
  • 学科 Biology Neuroscience.; Mathematics.
  • 学位 Ph.D.
  • 年度 2007
  • 页码 90 p.
  • 总页数 90
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经科学;数学;
  • 关键词

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