Development of highly active transition metal catalysts for organic synthesis.

摘要

In the past 20 years there has been dramatic growth in the use of transition metal catalysts in synthetically important organic transformations. Transition metal catalyzed cross-coupling reactions have been increasingly employed as instruments for C-C bond forming process. Among them, palladium(0)- and nickel(0)-catalyzed Suzuki cross-coupling reaction of aryl/alkenyl halides with organoboronic acids is an extremely powerful tool to synthesize biaryls.; My research project is on developing highly active palladium(0) and nickel(0) catalysts based on readily-available, cost-effective ligands for efficient cross coupling reactions. There are three aspects of my PhD thesis research projects. Firstly, synthesis of a family of readily available ferrocenylmethylphosphines and its polymer ligands and their applications as unique ligands for room temperature Pd(0)- and Ni(0)-catalyzed Suzuki cross-coupling reactions of aryl halides with aryl boronic acid; secondly, development of highly active Pd(0) and Ni(0) catalysts based on commercially available, inexpensive phosphine ligands, such as triphenylphosphine, for the room temperature Suzuki coupling reaction of aryl and alkenyl halides and aryl benzenesulfornates derivatives with aryl/alkenyl boronic acids. A NiL2X2 (L = monodentate phosphine ligand, X = halide) type nickel (II) complex were also developed as an air-stable catalyst precursor for room temperature Suzuki cross-coupling reactions of aryl/alkenyl arenesulfonates with aryl boronic acids; Thirdly, the palladium(0)-catalyzed sequential/tandem reaction to synthesize heterocycles, such as indoles and benzofurans.