声明
Chapter 1. Introduction
1.1. General introduction
1.2. Allotropes of boron
1.3. Review of boron and boron-based nanostructures
1.3.1. Boron nanostructure
1.4. Boron based nanostructures
1.4.1. Boronate based dynamic nanostructures
1.4.2. Boron carbide nanostructures
1.4.3. Boron nitride nanostructures
1.5. Application of boron based nanostructures
1.5.1. In biomedical applications
1.5.2. In hydrogels
1.5.3. In drug delivery
1.6. Content and significance of the study
Chapter 2. Experimental section
2.1. Materials
2.1. Preparation and characterization of drug-loaded nanoparticles with both H+and H2O2 sensitivity
2.1.1. Synthesis of end group modified catechol polyethylene glycol monomethyl ether (mPEG-CA)
2.1.2. Synthesis of 3-boronic acid benzoic acid (4-boronic acid) sterol ester (CHPBA)
2.1.3. Synthesis of di (4-borate) decyl fumarate (FCPBA)
2.1.4. Assembly of nanoparticles
2.1.5. Characterization of the product
Chapter 3. Experimental results and discussion
3.1. Characterization of mPEG-CA and bisphenylboronic acid monomers
3.1.1. Structural characterization of mPEG-CA
3.1.2. Structural characterization of CHPBA
3.1.3. Structural characterization of FCPBA
3.2.1. Characterization of the control nanoparticles
3.2.2. Characterization of nanoparticles in the experimental group
3.2.3. Potential characterization
3.2.4. Characterization of acid responsiveness and oxidation responsiveness
3.3. Characterization of PEG-FCBP nanoparticles
3.3.1. Characterization of the control group
3.3.2. Characterization of the experimental group
3.3.3. Potential characterization
3.3.4. Characterization of acid responsiveness and oxidation responsiveness
Chapter 4. Conclusions and recommendations
参考文献
Published papers and participation in scientific research papers
致谢
天津大学;
