Molecularly Imprinted Polymers (MIPs) Against Uracils : Functional Monomer Design, Monomer-Template Interactions In Solution And MIP Performance In Chromatography

摘要

The interaction of N~1-substituted uracils (cyclohexyl (1) and benzyl (2)) with three polymerisable recognition elements, the novel monomers 9-(3/4-vinylbenzyl)adenine (3) and 2, 6-diamino-9-(3/4-vinylbenzyl)purine (4) and the previously synthesised monomer 2, 6-bis(acrylamido)pyridine (5), has been studied via ~1H NMR in deuterio-chloroform solution. MIPs against (2) have been prepared using each of the monomers and tested in the chromatographic mode. The effect of the number and type of hydrogen bonds formed between the templates and the functional monomers is reflected in the values of the apparent association constants obtained from the solution study and by the performance of the subsequently prepared MIPs in the chromatographic mode.