DRUG CARRIERS BASED ON CYCLODEXTRIN INCLUSION COMPLEXES FOR THE CONTROLLED RELEASE OF HYDROPHOBIC DRUGS

摘要

A water-soluble β-CD derivative -carbonyl-β-CD was synthesized and characterized by Fourier transform infrared spectroscopy (FT-IR) and mass spectroscopy (MS). Drug release was studied by Ultraviolet-Vis (UV-Vis) spectroscopy using carbonyl-β-CD as drug carrier, water-insoluble benzoin as target drug, and water-soluble amantadine as competing agent. The formation of a benzoin-carbonyl-β-cyclodextrin inclusion complex greatly improved the solubility and bioavailability of benzoin. The target drug benzoin was released from the benzoin-carbonyl-β-cyclodextrin inclusion complex by adding the competing agent amantadine to the solution. The results showed that carbonyl-β-CD is an excellent drug carrier, and can be applied in controlled release of drugs.