SYNTHESIS AND PHYSICOCHEMICAL EVALUATION OF MALEIC ANHYDRIDE-GRAFTED-POLY(D,L-LACTIDE-CO-GLYCOLIDE) AS FUNCTIONAL STENT COATING FOR LOCALIZED GENE DELIVERY

摘要

The present study describes a novel strategy to covalently immobilize genes onto inert PLGA films via -CONH-cross-links. PLGA with functional carboxylic acid groups was synthesized using free-radical grafting maleic anhydride (MA) groups onto the polymer backbone. Cationic PEI/DNA complexes were successfully immobilized onto the functional PLGA films and characterized by ATR-FTIR and SEM analysis. We conclude that robust PLGA with functional carboxylic groups is a suitable platform for localized gene delivery.