Preparation and Charaterization of DAM-1 type Materials

摘要

Vitamin E TPGS was found to be an effective structure-directing agent for the preparation of both hexagonal all silica DAM-1 and the alumina analog, 'Al-DAM-1. These free flowing powders offer many advantages in the handling and oral delivery of the sticky vitamin E TPGS. Upon exposure to simulated gastric fluid, the Al-DAM-1 host molecular sieve is dissolved releasing the vitamin E TPGS. As much as 0.6 grams of vitamin E TPGS can be immobilized into 1 gram of Al-DAM-1. Vitamin E TPGS also templates highly ordered mesoporous DAM-1 with tunable morphologies such as hexagons (various lengths), gyroids, rods, spheres and discoids depending upon the temperature and gel composition. Characterization of these composites as well as a preliminary evaluation of Al-DAM-1 as an oral drug delivery system under physiological conditions is presented.