Microfabricated substrates for spectroscopy and separation

摘要

In this paper, we report the preliminary results from a microfabricated substrate system that is amenable to bothelectromagnetic field-enhanced spectroscopy such as surface enhanced Raman scattering (SERS) and analyte separationand detection. Substrates consisting of arrays of gold post-like and pit-like features of varying pitch on gold substrateswere fabricated by electron beam lithography. These substrates were characterized and tested for reproducible SERSactivity, as well as evaluated for incorporation into a microfluidic system for separation and identification of componentsof complex matrices. Identification of analytes relevant to biodetection and biological screening is reported.