In vitro and In vivo Evaluation of Neural Stem Cells Seeded on Neural Probes

摘要

The greater percent cell coverage of laminin immobilized samples vs. clean silicon samples is due to the high affinity of laminin for stem cells. This also contributes to the increased adherence of the stern cells on the laminin immobilized samples. Based on in vivo results, some NSCs seeded on the probe survived the shear forces applied on the probe during implantation insertion and remained alive after being in the host tissue. These results are encouraging and further analysis will be taken to track the fate of these cells (where they go and what type of cells they become) after longer period of times. In addition, the host tissue reaction to the NSC seeded probes will be further compared to the unseeded ones at longer time points.