PEGylated Nano-hybrid Adenovirus: Retargeting Adenovirus to Tumor Cells

摘要

We have demonstrated that adenovirus can be retargeted to specific tumor cells. By PEGylation with attaching a targeting moiety, innate immune responses were attenuated. Folate-PEG conjugated adenovirus is safe, efficient, and potential carrier for target-specific therapeutic gene delivery.