Degradation Kinetics of Poly(lactide-co-glycolide) Mediated by Titania Nanoparticles

摘要

Data demonstrated that the dispersion of nanophase titania in PLGA decreased the degradation rate of PLGA which is considered to favor new bone growth. Our previous studies have demonstrated that dispersion of titania nanoparticles into PLGA significantly improved osteoblast (bone-forming cell) adhesion and longer-term functions (such as collagen synthesis, alkaline phosphatase activity and calcium-containing minerals deposition) . In this manner, nanophase titania/PLGA composites can be promising scaffold materials for more effective orthopedic tissue engineering applications.