Synthesis and Characterization of a Biomimetic Calcium-Deficient Hydroxyapatite - Hydrogel Composite

摘要

This method of hydroxyapatite formation mimics the biomineralization of bone. In physiological systems, calcium ions first complex with an intermediary matrix: either collagen fibrils or a matrix vesicle. These cations form regular nucleation sites which then associate with phosphate ions to produce an OCP precursor phase that eventually hydrolyzes to hydroxyapatite. The BC hydrogel provides a template for the biomimetic synthesis of ordered CdHAP crystallites. The formation of this material is similar to the physiological biomineralization of bone producing apatite crystals of comparable shape and size. The bioactivity of the CdHAP and the biocompatibility of the BC hydrogel substantiate this composite as a potential orthopedic biomaterial.