Controlling the porosity of electrospun PCL scaffold by Simultaneous Salt releasing Method

摘要

The small pore sizes in electrospun scaffolds hinder cell infiltration in vitro and tissue-ingrowth into the scaffold in vivo, limiting their clinical potential. It is not easy to create well-defined pore sizes through the electrospinning technique because of the randomly deposited fibers. The range of NaCl crystals used could be regulated by using a sieve to separate the crystals according to size. Regulating the size of the NaCl crystals would lead to greater control of the size of the pores created when the NaCl is leached out. This could be one method that adjust the size of the pores to the needs of the specific scaffold design. Simultaneous salt releasing method can control the porosity of the electrospinning PCL scaffold and help the development of biocompatible scaffold.