Directing Neural Stem Cell Recruitment: Crosstalk Signaling Between ECM and SDF-1α

摘要

Our findings suggest that SDF-1α acts synergistically with certain ECM proteins (particularly laminin) to enhance NPSC migration. We also observed an enhancement of neuronal differentiation on all substrates in the presence of SDF-1α with the greatest increase on laminin and Matrigel. Additionally, our findings suggest that SDF-1α significantly influences NSPC proliferation on ECM substrates. Thus, crosstalk signaling between SDF-1α and ECM substrates may play a large role in neural stem cell recruitment following a traumatic brain injury. Modulating NPSC response after injury will be a valuable tool in developing the next generation of regenerative strategies for neural repair.