Fabrication of Novel Polylactic Acid/Amorphous Magnesium Phosphate Bionanocomposite Fibers for Tissue Engineering Applications via Electrospinning

摘要

We have successfully fabncated fibrous composites of PLA and AMP nanospheres via electrospinning. This study provides significant data regarding the physical and biological properties of PLA-AMP composites and their in vitro interaction with preosteoblast cells. The presence of AMP nanospheres in PLA matrix is beneficial to bone formation by increasing the gene expression of OCN, Col-I and OPN of preosteoblast cells. Additionally, it is observed that HSA, a surfactant used to improve ceramic dispersion in polymer matrix, shows adverse effects to preosteoblast cells when present in conjunction with AMP (MgP). It is believed AMP can be a potential candidate in bone tissue engineering applications. Future studies will be focused on the effect of AMP on the bone tissue regeneration and its related mechanism.